HH Holmes began his career of murder in 1888, while Jack The Ripper was infamously at work in London.
Though not as well known today as the Ripper, the Chicago-based Holmes was far more prolific.
He finally confessed to 28 horrific killings, and was implicated in 200 more, after a private detective made a series of gruesome discoveries in Holmes' mansion-cum-boarding house, a place purpose-built for perversion, murder and the disposal of bodies.
Hanged in May 1896, his final words were "I built a castle for the pleasure of killing my fellow beings".
Murder Hotel is the chilling story of America's first serial killer, featuring a CGI recreation of the elaborate 60-room